What are the risks if someone has eczema?

Developing a health problem due to the smallpox vaccine is rare. Smallpox was wiped out more than 30 years ago, so the smallpox vaccine is no longer available to the public. A few people, however, still get this vaccine.

For anyone who has (or had) eczema, it’s important to take some precautions if a person close to you gets the smallpox vaccine.

Anyone who has (or had) eczema must take precautions around a person recently vaccinated against smallpox.

Who gets the smallpox vaccine?

The smallpox vaccine is given to:

Live smallpox vaccine can lead to serious infection 

One type of smallpox vaccine contains a live virus. This live vaccine can cause serious problems for anyone who:

Anyone who has (or had) eczema, should avoid:

Skin-to-skin contact with someone who received the live smallpox vaccine can cause a serious infection known as eczema vaccinatum (EV). This infection develops in people who have (or had) eczema.

While EV is very rare today, it is important for anyone who has (or had) eczema to avoid skin-to-skin contact with anyone who receives the live smallpox vaccine. EV can be very serious.

It’s necessary to avoid skin-to-skin contact for about 30 days. This is how long it takes for the vaccinated area to scab and the scab to fall off.

Once the skin heals and the scab falls off, it’s safe to have skin-to-skin contact.

If you have skin-to-skin contact before the scab falls off:

Anyone who develops EV looks very ill and has a fever. These are signs that the person needs immediate medical care.

Related AAD resources

References
Reed JL, Scott DE, et. al. “Eczema Vaccinatum.” Clin Infect Dis. 2012 Mar;54(6):832-40.

Vellozzi C, Lane M, Averhoff F, et al. “Generalized vaccinia, progressive vaccinia, and eczema vaccinatum are rare following smallpox (vaccinia) vaccination: United States surveillance, 2003.” Clin Infect Dis. 2005; 41(5):689-97.